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CBD je po THC druhým nejdůležitějším z nich. Chemicky jsou látky CBD a THC blízce příbuzné, CBD ale není psychoaktivní stejným způsobem jako THC, tj. na rozdíl od THC přímo nestimuluje kanabinoidní receptory CB1 a CB2. Funguje také jako inhibitor řady účinků THC.
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